30. jan. 2018 Düsseldorf
Instem Genetox Solution Supports Development of Bioartificial Human Skin Models
Phenion, an expert in 3D skin model technology and alternatives to animal testings, is pleased to announce that it deploys the Comet Assay IV live video imaging system from Instem, a leading provider of IT solutions to the global life sciences market, to analyze DNA damage in Phenion Full Thickness Skin Models, that have been subjected to the 3D Skin Comet assay.
Originally developed by Perceptive Instruments, and now part of the Instem solution portfolio, Comet Assay IV is a live video imaging system for fast, accurate and reproducible comet slide scoring. Comet Assay IV's unique single-click scoring method and instant live video technology make it the most efficient and easy-to-use system available for measuring DNA damage using single cell gel electrophoresis.
Comet Assay IV has been successfully used in the validation study of the 3D Skin Comet Assay. This assay, built on Phenion Full-Thickness Skin Models, has shown excellent toxicological predictivity during its validation by five US and European laboratories. The assay detects structural DNA damages and other lesions, which may give rise to gene mutations and the method is well-suited to supplement existing in vitro test batteries and to follow-up initial positive findings. The 3D Skin Comet Assay has already successfully supported safety assessments of hair dye ingredients, and the involved scientists envision that the method will be adopted into an OECD test guideline for its global use in safety assessment of chemicals, e. g. in the framework of REACH.
Instem is a global provider of leading software solutions and services that are helping over 500 clients bring their life enhancing products to market faster. We enable clients in the life sciences to more efficiently collect, analyze, report and submit high quality regulatory data, while maintaining compliance for their products around the world.
Instem solutions are in use by customers worldwide, meeting the rapidly expanding needs of life science and healthcare organizations for data-driven decision making, leading to safer, more effective products.
Instem supports its global roster of clients through offices in the United States, United Kingdom, France, Japan, China and India.